ENGINEERING OF AN AVIDITY-OPTIMIZED CD19-SPECIFIC PARALLEL CHIMERIC ANTIGEN RECEPTOR THAT DELIVERS DUAL CD28 AND 4-1BB CO-STIMULATION

Engineering of an Avidity-Optimized CD19-Specific Parallel Chimeric Antigen Receptor That Delivers Dual CD28 and 4-1BB Co-Stimulation

Co-stimulation is critical to the function of chimeric antigen receptor (CAR) T-cells.Previously, we demonstrated that dual co-stimulation can be effectively harnessed by a parallel (p)CAR architecture in which a CD28-containing second generation CAR is co-expressed with a 4-1BB containing chimeric co-stimulatory receptor (CCR).When compared to lin

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Quand le risque industriel est synonyme de dynamiques urbaines

Issues related to the relationship between risk and industrial urban areas arise mainly for certain types of industrial facilities (often in connection with the chemical industry or hydrocarbons) and mainly for industrial risks.The town of Cognac knows this problem with a specific activity iphone 13 atlanta that is on the surface far from the image

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Tectonics and paleogeography of the Marajó Basin, northern Brazil

The Marajó Basin area presents geologic and geomorphologic features chiefly due to the Mesozoic extension and post-Miocene neotectonics.The extension event with an Early and a Late Cretaceous phases originated four sub-basins that constitutes the Marajó Basin, with a thick continental clastic sequence showing marine influence.NW and NNW normal fa

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